After 90 days of daily use:
100%
saw improved elasticity
100%
noticed smoother texture
98%
reported reduced fine lines
98%
saw brighter, healthier skin
100%
felt noticeably younger
Free shipping worldwide
$ 390.00
Out of stock
NIANCE Epigen9 Rejuvenating Mask is an advanced, rinse-off or leave-on facial treatment mask formulated with cutting-edge longevity science. It delivers the world’s first senolytic-powered masking experience—clearing aged, dysfunctional “zombie” skin cells while recharging skin energy with NAD+ and ATP. Designed as a 30-minute skin reset, it provides the intensive benefits of a serum, cream, and repair elixir in one luxurious application.
This intelligent formula targets the root causes of aging through three synergistic actions:
Senolytic Elimination: EPIGEN9™ selectively removes senescent “zombie” cells that impair tissue function, allowing healthy cells to thrive.
NAD+ Replenishment: RejuveNAD™ enhances intracellular NAD+ levels by activating NAMPT, promoting DNA repair, energy production, and epigenetic renewal.
Stem Cell Revival via Exosomes: PhytoCellTec™ Goji delivers miRNA-21 and miRNA-34a to activate skin stem cells and stimulate collagen synthesis, mimicking the effects of exosome microneedling—without needles.
PhytoCellTec™ Goji, derived from goji plant stem cells, revitalizes mesenchymal stem cells (MSCs) and boosts their exosome production. Exosomes are small, approximately 100 nm vesicles that carry proteins, lipids, and RNAs to stimulate fibroblasts, enhancing collagen and elastin synthesis. By activating this natural signaling pathway, PhytoCellTec™ Goji mimics the rejuvenating benefits of exosome microneedling—without needles.
Clinically Proven Benefits: Wrinkle Reduction and V-Shape Contouring
Clinical studies show PhytoCellTec™ Goji improves skin density, reduces wrinkles, and minimizes fine lines. Most importantly, it visibly lifts jawline contours, refining the oval structure of the face by 6% in just four weeks. By stimulating exosome activity, this breakthrough ingredient delivers firmer, smoother, youthful skin and the coveted V-shaped face:
• Stimulates exosome signaling
• Increases collagen and elastin expression
• Improves skin density
• Tightens facial contours
• Minimizes fine wrinkles and deeper lines
Epigen-9 Rejuvenating Serum is not just another luxury formula. It is the culmination of years of scientific exploration into cellular aging. By uniting senolytic elimination, NAD⁺ replenishment, and exosome-driven stem cell revival, we are able to address 12 of the 14 hallmarks of aging at their root. Remarkably, it mimics the effects of exosome microneedling therapy without needles. The clinical results speak for themselves. In just 14 days, skin appears 6 years younger, and in 90 days, 9 years younger. This is not a surface-level beauty. It is true cellular rejuvenation.”
Dr. Patrick Schwarzentruber
Chief Scientist at NIANCE
Ph.D. in Biology, Visiting Professor at Warwick University, Global Top 50 Longevity Expert
THE holistic solution for healthy aging skin, acting on the cellular level, efficient on any skin types, ethnicities and for any age, gender. It acts at the root cause of aging: clearing senescent (zombie) cells. This patented active, 100% of natural origin, produced from a rare plant, alpine willowherb, helps rejuvenate the healthy skin appearance, revert the skin damage induced by senescent cells. Reduces the appearance of wrinkles and helps increase the skin elasticity and smoothness with a better skin structure.
Swiss Glacier Complex® is the core revitalizing engine of NIANCE skincare products, composed of four (4) groups of potent active ingredients from the Alps, achieving four (4) comprehensive anti-aging effects: 24-hour long-lasting hydration and moisturizing, skin microbiome support, wrinkle reduction and prevention, and firming & lifting.
Swiss Glacier Complex®, the core engine and soul of Niance skincare products, is made up of 4 powerful fundamental elements – Swiss Apline glacier water, vitamin cocktail, complex of minerals and active substances from high Alpine plants. Swiss Glacier Complex® is like a stream of light poured into a bottle. It safeguards the well-being of the epidermis, stimulates cell renewal, delays the first signs of skin aging, and reactivates the skin’s own ability to regenerate and rejuvenate by stimulating the synthesis of collagen, hyaluronic acid and elastin. The skin becomes smooth, firm and youthful. Thanks to the proprietary FERNESSE™ biotechnology that transforms Edelweiss, Thymus Vulgaris, Gentiana Lutea Root, Buddleja Davidii and Borago Officinalis Seed oil by enzymatic activation, Swiss Glacier Complex® achieves the high performance of anti-aging but in an environmentally-friendly way, without the use of paraffins, parabens, mineral oils, sensitizers, microplastics, hormones and genetically modified ingredients. It is a vegan-friendly complex.
3 months, n=50, ages 45–60:
After 90 days of daily use:
saw improved elasticity
noticed smoother texture
reported reduced fine lines
saw brighter, healthier skin
felt noticeably younger
Daily Use:
Apply in morning and evening after cleansing and toning.
Use 1 pump for face and neck. Follow with cream.
Spot Treatment:
Apply morning and evening for 8 weeks on target areas.
Regimens:
30+ skin: 1–2 treatment/year (28–56 days)
40+ skin: 4–6 cycles/year
50+ skin: Daily or 6–8 cycles/year
Format:
4 x 10ml airless pump vials (28-day treatment)
| Packing | Jar |
|---|---|
| Unit | 50 ml |
EPIGEN9™, RejuveNAD™, PhytoCellTec™ Goji, Swiss Glacier Complex®, Lactococcus Ferment Lysate, Multi-Molecular Hyaluronic Acid
Please keep the product in the dry and cool environment. Keep away from children.
| Clear Senescent Cells | Anti-Aging | Rejuvenate | Repair
| UVA / UVB Protection | Light & Breathable | ALL-IN-ONE | Anti-ageing | Skin Longevity
| Slows Epigenetic Ageing | Reduces Biological Age | Better Sleep | More Energy
| Marine Collagen | Hyaluronic Acid | For Skin, Hair, Bones, Nails and Joints
| Botox-like effect | Anti-ageing | 24-hour Max Moisture | Younger-looking Skin
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After 90 days of daily use:
saw improved elasticity
noticed smoother texture
reported reduced fine lines
saw brighter, healthier skin
felt noticeably younger
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