Epigen9 Rejuvenating Mask

Epigen12™ Cell Renewal is a next-generation epigenetic longevity supplement designed to reverse biological (epigenetic) age by targeting DNA methylation, mitochondrial signaling, and cellular senescence — the root drivers of aging.

It is designed for individuals who want to actively manage how fast their body ages biologically, especially professionals, executives, and high-performing individuals seeking long-term vitality rather than short-term stimulation.

Chronological age cannot be changed, but biological age can accelerate or slow down. Epigen12™ addresses accelerated biological aging caused by stress, lifestyle pressure, metabolic imbalance, and cellular dysfunction.

Epigen12™ modulates epigenetic regulation (DNA methylation), supports NAD⁺-dependent mitochondrial communication, and reduces senescence-associated cellular dysfunction — helping cells behave more youthfully.

Unlike NAD⁺ boosters or performance supplements, Epigen12™ is clinically validated to impact epigenetic aging itself, not just energy or symptoms. It targets how aging is programmed at the cellular level.

Epigen12™ contains a proprietary epigenetic complex combined with trans-resveratrol, nicotinamide riboside (NR), niacinamide (vitamin B3), and coenzyme Q10 — designed to act synergistically on epigenetic and mitochondrial pathways.

Epigen12™ has been evaluated in an 81-participant, double-blind, randomized, placebo-controlled human study, where it was shown to reverse biological (epigenetic) age by up to 12 years, measured using DNA methylation biomarkers.

Biological age reflects how fast the body is aging at the cellular and molecular level. Reversal means improving epigenetic biomarkers so cells function more like those of a younger biological state.

Biological aging is measured at the molecular level. Improvements in vitality, sleep quality, and resilience may be felt within weeks, while epigenetic age changes are typically assessed over months through biomarker testing.

Epigen12™ represents the epigenetic reprogramming phase of the system. It is most effective when used after the body has been prepared through microbiome optimization and Holistic Body Reset.

Epigenetic reprogramming requires a metabolically clear and resilient system. Holistic Body Reset restores detoxification capacity, reduces toxic load, and re-ignites metabolism, creating the optimal biological environment for Epigen12™ to work effectively.

Yes. Epigen12™ is designed to work synergistically with GENR8® Biotic Supplements, Holistic Body Reset, and Collagen-Hyaluron Beauty Booster as part of an integrated longevity system.

Epigen12™ is developed and manufactured in Switzerland under strict quality and safety standards. Its formulation is designed for long-term use to support sustainable biological aging management.

Yes. Epigenetic aging affects both men and women, and Epigen12™ is suitable for both genders.

Yes. Biological aging acceleration often becomes more pronounced after 40, making Epigen12™ particularly relevant for individuals in midlife and beyond.

No. Epigen12™ complements a healthy lifestyle by supporting biological mechanisms that lifestyle alone cannot fully address, especially under modern stress conditions.

Biological aging is continuous. Discontinuation means the body is no longer supported at the epigenetic level, and aging processes continue according to lifestyle and environmental factors.

Traditional anti-aging products focus on appearance or symptoms. Epigen12™ focuses on how cells age, addressing the biological root rather than surface effects.

Switzerland offers world-leading standards in biotechnology, nutraceutical regulation, and clinical research. NIANCE products are developed and manufactured in Switzerland to ensure precision, safety, and scientific integrity.

Epigen12™ Cell Renewal is a clinically validated epigenetic longevity supplement designed to reverse biological age and reset how the body ages from within.

During the first 6–9 months of consistent use, EPIGEN12™ Cell Renewal helps slow down your epigenetic aging speed, supporting deep cellular renewal, improved mitochondrial function, and visibly healthier skin. Many users report better sleep, more energy, and significant improvements in biological age.

To maintain and extend these benefits, we recommend a hybrid maintenance approach based on both your lifestyle and age:

Lifestyle-based guidance:
If you lead a high-stress, fast-paced lifestyle or frequently experience poor sleep, travel, or physical exhaustion, continuing EPIGEN12™ on a daily basis may offer ongoing support and protection against accelerated aging. Your body will benefit from the consistent boost in NAD⁺ levels and cellular repair.

Age-based guidance (if your lifestyle is balanced):

• Ages 40–50: 3 months of EPIGEN12™ annually
• Ages 50–65: 3–6 months annually
• Ages 65+: 9–12 months annually

You may also cycle your usage — for example, take 3 months on / 1 month off — or use a lower maintenance dose (1 capsule every other day) if that suits your rhythm better.

Bonus tip:
To complement EPIGEN12™ and support visible skin and body health all year round, we recommend taking 1 sachet of the NIANCE Collagen-Hyaluron Beauty Booster daily. It provides essential nutrients that maintain firmness, elasticity, and glow—especially helpful during or after periods of intensive cellular renewal.

While both NMN (Nicotinamide Mononucleotide) and EPIGEN12™ aim to support healthy aging by boosting NAD⁺ levels, their mechanisms, formulation, and benefits are quite different:

In short, NMN is one ingredient. EPIGEN12™ is a next-generation cellular renewal program — combining several potent longevity actives that work synergistically to address aging at its root.

Yes, we recommend taking EPIGEN12™ first thing in the morning—even while intermittent fasting—as long as you're well hydrated. However, for optimal absorption, two key ingredients—Nicotinamide Riboside (NR) and Trans-Resveratrol—can benefit from being taken with a small meal that contains healthy fats.

Taking EPIGEN12™ with foods like a few nuts, half an avocado, or a spoonful of extra virgin olive oil may significantly enhance the bioavailability of Trans-Resveratrol, and support the metabolic conversion of NR to NAD⁺. If your stomach is sensitive, this is also a gentler option.

Listen to your body—both approaches are effective, but pairing with healthy fats may help you maximize results.

That’s your body eliminating toxins! EPIGEN12™ activates detox pathways as part of the cellular reset process. This can lead to temporary increases in urination or bowel movements, typically normalizing within 2–4 weeks. Stay hydrated and nourish your body with fiber to support this transition.

Yes—it’s part of the cellular "reset" phase. In the beginning, your body may prioritize internal repair over performance. Improved sleep is often the first benefit, followed by renewed energy and stamina once your cells adapt. Give it 2–4 weeks, and you’ll likely notice the difference.

EPIGEN12™ is clinically studied and well-tolerated. It’s recommended for anyone aged 40+ who wishes to take proactive steps toward healthy aging. As with any supplement, if you have a medical condition (like a pacemaker or heart stents), consult your healthcare provider for tailored advice.

Yes! EPIGEN12™ Cell Renewal is completely vegan and cruelty-free, formulated with plant-based actives and clean nutraceutical science.

Every capsule of EPIGEN12™ delivers a powerful daily dose of longevity science:

• Nicotinamide Riboside (NR): 250 mg
• EPIGEN12™ Complex : 150 mg
• Trans-Resveratrol: 100 mg
• Nicotinamide (Vitamin B3): 16 mg
• Coenzyme Q10: 15 mg

These ingredients work synergistically to reverse biological age, boost NAD⁺ production, enhance cellular energy, and support DNA repair.

Backed by a 12-week 81-participant (with age profile between 45 and 65 years old) randomized, double-blind clinical study, EPIGEN12™ has been shown to:

• Reduce biological age by up to 12 years
• Preserve telomere length
• Enhance mitochondrial energy by 35%
• Improve sleep, vitality, and overall wellness
• Reduce cortisol levels by 25%

That’s one of the most exciting benefits of EPIGEN12™ — and it comes down to accelerated cellular repair.

Here’s why recovery improves:

• Trans-Resveratrol, CoQ10, and Nicotinamide Riboside in EPIGEN12™ help restore mitochondrial energy quickly after exertion, reducing fatigue.
• It reduces inflammation and oxidative stress, both of which are elevated after intense physical activity.
• Enhanced DNA repair and autophagy support the recovery of muscle cells and tissues damaged during exercise.

The result? Less soreness, faster bounce-back, and more energy for your next workout.

All NIANCE longevity supplements, including EPIGEN12™, are 100% developed and manufactured in Switzerland in Swissmedic-certified facilities. All ingredients are Swiss-sourced—except our marine collagen, which comes from the pristine North Atlantic.

Based on your experience, it’s likely related to the timing of your intake.

We strongly recommend taking EPIGEN12™ only in the morning, ideally with a small breakfast that includes healthy fats. This is because EPIGEN12™ increases mitochondrial ATP (energy) production by up to 35% daily — which is fantastic for vitality and performance, but only if your body has time to use that energy throughout the day.

Taking it in the afternoon or evening may overstimulate your cellular energy levels, making it harder for your body to transition into rest mode at night — especially during the first 1–2 weeks of cellular adaptation.

To fully benefit from EPIGEN12™ while supporting your sleep cycle, morning intake is key.

Yes, EPIGEN12™ can enhance sports performance — not by acting like a stimulant, but by improving your cellular health and energy production at the root level.

Here’s how:

• It boosts NAD⁺ levels, a vital coenzyme for mitochondrial energy production — powering your muscles more efficiently during exercise.
• It supports faster recovery and reduced fatigue, allowing you to train with better consistency.
• Over time, EPIGEN12™ promotes improved metabolic flexibility, cellular resilience, and reduced oxidative stress — all of which contribute to endurance and performance, especially for those over 40.

Athletes often report better stamina, smoother performance, and more balanced energy with consistent use.

Yes — many users report improved mental sharpness, clarity, and focus within just a few weeks of taking EPIGEN12™.

This is largely due to its role in boosting NAD⁺ levels and mitochondrial function, which support energy production not just in the body, but also in the brain. EPIGEN12™ enhances neuronal health, supports neurotransmitter balance, and improves blood flow to the brain — all of which contribute to better cognitive performance.

As your cellular energy systems become more efficient, many users experience a “clearer mind,” improved concentration, and more sustained mental stamina throughout the day.

EPIGEN12™ can be a powerful ally against jet lag. One of the key causes of jet lag is disrupted circadian rhythm and reduced cellular energy availability — both of which EPIGEN12™ helps address.

By restoring NAD⁺ balance, EPIGEN12™ supports the body’s internal clock and promotes faster circadian realignment. It also helps your mitochondria produce more energy (ATP), reducing the mental and physical fatigue commonly felt during time zone transitions.

To ease jet lag symptoms, we recommend:

• Taking EPIGEN12™ first thing in the morning at your destination.
• Pairing it with light exposure and hydration to help reset your body clock.

Many users tell us EPIGEN12™ helps them adapt more quickly, feel less drained, and bounce back with better sleep and alertness after long flights.