Manganese helps the body form connective tissue, bones, blood clotting factors, and sex hormones. It also plays a role in fat and carbohydrate metabolism, calcium absorption, and blood sugar regulation. Manganese is also necessary for normal brain and nerve function. It is also important in the healing process of wounds. Wound healing requires an increased production of collagen. Manganese is needed for producing the amino acid proline, which is essential for collagen formation and wound healing in human skin cells.