Niance

Epigen9 Rejuvenating Mask

The Miracle Trio

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$ 390.00

Out of stock

What it is

NIANCE Epigen9 Rejuvenating Mask is an advanced, rinse-off or leave-on facial treatment mask formulated with cutting-edge longevity science. It delivers the world’s first senolytic-powered masking experience—clearing aged, dysfunctional “zombie” skin cells while recharging skin energy with NAD+ and ATP. Designed as a 30-minute skin reset, it provides the intensive benefits of a serum, cream, and repair elixir in one luxurious application.

How it works

This intelligent formula works through a triple-action mechanism:

Senolytic Activation: EPIGEN9™ eliminates senescent cells and reduces their harmful secretions (SASP), including IL-6, IL-1, MMPs, and ROS.

NAD+ & ATP Boost: RejuveNAD™ replenishes NAD+ and enhances mitochondrial energy production (ATP), supporting cellular repair, metabolism, and skin vitality.

Microbiome & Barrier Strengthening: Swiss Glacier Complex® and Lactococcus ferment lysate work together to reduce inflammation, protect against oxidative stress, and rebuild skin structure.

Benefits

Clears aging senescent cells (“zombie cells”) from skin
Recharges skin’s energy with NAD+ and ATP dual activation
Deeply hydrates, firms, and brightens in just 30 minutes
Reduces fine lines, dullness, and signs of fatigue
Strengthens the skin barrier and microbiome
Provides visible radiance and long-term rejuvenation
Designed to provide serum, cream, and repair elixir in one step as a cure

EPIGEN9™

THE holistic solution for healthy aging skin, acting on the cellular level, efficient on any skin types, ethnicities and for any age, gender. It acts at the root cause of aging: clearing senescent (zombie) cells. This patented active, 100% of natural origin, produced from a rare plant, alpine willowherb, helps rejuvenate the healthy skin appearance, revert the skin damage induced by senescent cells. Reduces the appearance of wrinkles and helps increase the skin elasticity and smoothness with a better skin structure.

Holistic healthy aging – acts at the cellular level
Helps revert skin damage induced by zombie cells
Helps restore and boost collagen
Helps slow down the premature aging of skin
Reverses the skin appearance by 6 years after 2 weeks and 9 years after 3 months
Reduces the appearance of fine lines and wrinkles
Helps increase skin elasticity and skin smoothness
Provides a rejuvenated skin appearance with vibrant healthy looking-skin

NIANCE Epigen-9 Rejuvenating Mask is a world first in longevity skincare. Powered by Epigen-9 Rejuvenate and our Swiss Glacier Complex, it clears dysfunctional zombie cells while simultaneously boosting NAD⁺ and ATP to recharge the skin’s energy. In just 30 minutes, it delivers the benefit of a serum, a cream and a repair elixir in one transformative treatment. I believe this breakthrough is a glimpse into the future of skin longevity. Fast, profound and measurable cellular reset

Dr. Patrick Schwarzentruber
Chief Scientist at NIANCE
Ph.D. in Biology, Visiting Professor at Warwick University, Global Top 50 Longevity Expert

Highlights

RejuveNAD™

RejuveNAD+, a next-generation active derived from organic sunflower sprouts, scientifically designed to naturally boost NAD+ production in the skin.

Activates NAMPT: RejuveNAD+ stimulates NAMPT activity, restoring the skin’s ability to recycle and produce NAD+ efficiently.
Boosts NAD+ Levels: By enhancing the NAD+ salvage pathway, RejuveNAD+ rejuvenates cellular energy production and promotes DNA repair, reversing signs of aging.
Mitochondrial Support: Higher NAD+ levels restore mitochondrial efficiency, revitalizing cells from within and enhancing skin vitality.

Swiss Glacier Complex® - 4 X 4 BENEFITS

Swiss Glacier Complex® is the core revitalizing engine of NIANCE skincare products, composed of four (4) groups of potent active ingredients from the Alps, achieving four (4) comprehensive anti-aging effects: 24-hour long-lasting hydration and moisturizing, skin microbiome support, wrinkle reduction and prevention, and firming & lifting.

Swiss Glacier Complex®, the core engine and soul of Niance skincare products, is made up of 4 powerful fundamental elements – Swiss Apline glacier water, vitamin cocktail, complex of minerals and active substances from high Alpine plants. Swiss Glacier Complex® is like a stream of light poured into a bottle. It safeguards the well-being of the epidermis, stimulates cell renewal, delays the first signs of skin aging, and reactivates the skin’s own ability to regenerate and rejuvenate by stimulating the synthesis of collagen, hyaluronic acid and elastin. The skin becomes smooth, firm and youthful. Thanks to the proprietary FERNESSE™ biotechnology that transforms Edelweiss, Thymus Vulgaris, Gentiana Lutea Root, Buddleja Davidii and Borago Officinalis Seed oil by enzymatic activation, Swiss Glacier Complex® achieves the high performance of anti-aging but in an environmentally-friendly way, without the use of paraffins, parabens, mineral oils, sensitizers, microplastics, hormones and genetically modified ingredients. It is a vegan-friendly complex.

EFFICACY STUDY RESULTS

NAD+ Synthesis is Dependent on NAMPT

Increase in NAMPT Expression

Increase in NAD+ Levels

Reduction of DNA Damage

Reduction of Epigenetic Marker

Increase in Cell Number

Increase in ATP Levels

Reduction of Mitochondrial Damage

Increase in Sirtuin 1 Levels

Increase in Collagen XVII Levels

Increase in Collagen Density

Reduction of Age Spots

Improvement of Skin Smoothness

Lifting Effect

Improvement in Wrinkle Depth

Younger Skin Effect

Clinical Trials

3 months, n=50, age 45–60:

↓52% senescent cells
↑200% collagen synthesis
↓90% ROS
↑84% ATP
NAD+ increased through NAMPT pathway
Skin texture, firmness, energy significantly improved
Visible age reversal of up to 9 years

Consumer Trials

100%

felt skin was visibly smoother after first use

98%

noticed firmer, lifted skin after 4 weeks

100%

saw improved brightness and clarity

96%

described it as a “total skin reset”

Key Ingredients

How to use

Apply generously to clean, dry skin on the face and neck.
Leave on for 30-60 minutes.
Rinse thoroughly with lukewarm water.
Use 2–3 times per week for optimal results.
Alternatively it can be used as a leave-on sleep mask for optimal benefit.
Can be used as part of a targeted 4-week longevity skincare reset or maintained as a weekly intensive treatment.