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Niance

Epigen12™ Cell Renewal

Turning back the biological age clock by up to 12 years

EPIGEN12™ Cell Renewal is a revolutionary longevity supplement designed to turn back the biological clock by up to 12 years. With clinically proven results, this advanced formula tackles 9 hallmarks of aging, revitalizing your body at a cellular level for unparalleled rejuvenation and vitality.

$ 285.00$ 3'080.00

What It Is

EPIGEN12™ Cell Renewal, a groundbreaking innovation in the fight against aging that redefines what’s possible in cellular rejuvenation. Clinically proven to turn back your biological clock by up to 12 years, this advanced formula addresses 9 out of 12 hallmarks of aging at the deepest level. Powered by the next-generation EPIGEN12™ extract, it delivers unparalleled benefits by reducing epigenetic aging, preserving telomere length, and revitalizing mitochondrial energy production. Enhanced with Trans-Resveratrol for superior bioavailability and a synergistic combination of Nicotinamide Riboside and Niacinamide, EPIGEN12™ Cell Renewal optimizes DNA repair, boosts NAD+ levels, and defends against oxidative stress, setting a new benchmark for anti-aging innovation. Experience a revolutionary approach to longevity, vitality, and quality of life with this transformative product—designed for those who demand the ultimate in cellular health and rejuvenation.

How It Works

EPIGEN12™ Cell Renewal leverages the power of cutting-edge epigenetics to restore youthful cellular function. By reducing epigenetic aging, preserving telomere length, and enhancing mitochondrial energy production, this supplement combats oxidative stress, supports DNA repair, and promotes overall cellular health. The formula is enriched with potent active ingredients to address multiple aging markers simultaneously, providing comprehensive anti-aging benefits.

Benefits

  • Reduces Biological Age: Clinically proven to turn back up to 12 biological years by addressing epigenetic aging.
  • Protects Telomere Length: Safeguards the integrity of telomeres to maintain cellular longevity.
  • Boosts Mitochondrial Energy: Enhances ATP production for improved energy levels and cellular function.
  • Boosts NAD+ Levels: Promotes NAD+ production, supporting energy metabolism and DNA repair.
  • Fights Oxidative Stress: Provides powerful antioxidant protection, reducing inflammation and genomic instability
  • Improves Quality of Life: Enhances physical activity, sleep quality, and overall wellness.

How To Use

  1. Take one capsule daily with a meal.
  2. Preferably consume it in the morning.
  3. Use consistently for optimal results.
  4. Continue usage for 6-9 months.
  5. Pair with a balanced diet and healthy lifestyle.

Science

EPIGEN12™

A next-generation, flavonoid-rich extract from scarlet beebalm and lemon balm, EPIGEN12™ has been clinically proven to:

  • Reduce epigenetic aging, equivalent to a reduction of up to 12 biological years.
  • Protect telomere length, preserving cellular longevity and counteracting telomere attrition.
  • Enhance mitochondrial function, boosting ATP production and defending against oxidative stress, addressing mitochondrial dysfunction.
  • Prevent cellular senescence, protecting cells from premature aging and supporting long-term vitality.
  • Promote vascular health by improving endothelial function, increasing nitric oxide release, and supporting healthy blood flow, mitigating dysregulated nutrient sensing and altered intercellular communication.
  • Provide powerful antioxidant protection, counteracting oxidative stress and inflammation, which can contribute to genomic instability, stem cell exhaustion, and chronic inflammation.

Consumer Trials

A randomized, double-blind, placebo-controlled study involved 81 volunteers aged 45–65 years, particularly susceptible to aging effects due to stressful jobs.

Over a 12-week period, participants taking 100 mg of EPIGEN12™ demonstrated:

Improved Leukocyte Telomere Length (LTL): A crucial indicator of cellular aging.

Enhanced Quality of Life (QOL): Including significant improvements in physical activity and sleep indices compared to placebo.

Prevention of Epigenetic Aging: Slowing biological aging, in contrast to the placebo group, which experienced an increase.

All participants tolerated the supplement well, with no adverse effects reported.

Clinical Trials

Conducted in laboratory settings using specialized assays and validated cellular models:

DNA Methylation Age (DNAmAge): Testing revealed a significant reduction in biological age up to 12 years.

Telomere Shortening Rate: EPIGEN12™ preserved telomere length, a key marker of cellular health, with statistically significant results (p < 0.01).

Mitochondrial ATP Production: Increased energy production in human heart cells, indicating enhanced cellular vitality (p < 0.001).

Vascular Function: Improved nitric oxide (NO) release in human endothelial cells, supporting healthy blood flow and nutrient sensing.

Nematode Healthspan Study: Demonstrated improved mobility and lifespan in medium-aged nematodes, correlating with enhanced healthspan.

EPIGEN12™ EFFICACY RESULTS

Telomere Shortening Rate

The control group showed a significantly higher telomere shortening rate compared to the group treated with 0.043 mg/mL of EPIGEN12™. This suggests that EPIGEN12™ may reduce the rate of telomere shortening, a marker of cellular aging.

Biological Age (DNA Methylation Age or DNAmAge)

The aged group treated with 0.03 mg/mL EPIGEN12™ displayed a reduction in biological age compared to the control group, indicating a potential age-reversing effect of EPIGEN12™.

Change in DNAmAge (Years)

Participants receiving EPIGEN12™ showed a lesser increase in DNAmAge compared to the placebo group, highlighting its potential in slowing biological aging.

Change in Leucocyte Telomere Length (LTL)

The placebo group experienced a reduction in LTL, while the EPIGEN12™ group showed an increase in telomere length.

ATP Production

EPIGEN12™ at 0.2 mg/mL significantly boosted ATP production compared to the control and Rotenone-treated groups.

Physical Activity and Sleep Index

A higher percentage of participants in the EPIGEN12™ group showed improvements in physical activity and sleep index compared to the placebo group.

Quality of Life (QOL)

The EPIGEN12™ group experienced a significant improvement in QOL compared to the placebo group, which showed a decline.

Nicotinamide Riboside (NR) + Niacinamide – A Synergistic Combination

The combination of NR and Niacinamide creates a powerful duo to support cellular metabolism and DNA repair.

Benefits:

  • NAD+ Precursor Enhancement: NR boosts NAD+ levels, essential for cellular energy production, while Niacinamide amplifies its efficacy.
  • Comprehensive DNA Repair: Together, they enhance the repair of damaged DNA, reducing genomic instability and protecting against aging triggers.
  • Dual Pathway Mitochondrial Support: NR promotes mitochondrial biogenesis, while Niacinamide strengthens mitochondrial integrity, ensuring sustained energy production.
  • Skin Health and Barrier Function: Niacinamide adds benefits for skin hydration, elasticity, and overall resilience, complementing NR’s intracellular anti-aging effects.

Trans-Resveratrol – A Superior Longevity Activator - The Triple-Biotics Power

A next-generation form of resveratrol, Trans-Resveratrol is more bioavailable and potent compared to conventional resveratrol.

Unique Benefits:

Enhanced Bioavailability: Trans-Resveratrol is more efficiently absorbed by the body, delivering faster and more effective results.
Activates Sirtuins for Longevity: Boosts mitochondrial function, supporting cellular energy and delaying aging processes.
Superior Antioxidant Properties: Provides robust protection against oxidative stress, reducing DNA damage and inflammation.
Improves Skin Health: Supports elasticity and hydration while reducing visible signs of aging.

Key Ingredients​

Our Promises

Additional information

Unit

30 Capsules

Packing

Bottle

Epigen12™, Trans-Resveratrol, Nicotinamide Riboside (NR), Niacinamide (Vitamin B3), Coenzym Q10

Please keep the product in the dry and cool environment. Keep away from children.

FAQ

During the first 6–9 months of consistent use, EPIGEN12™ Cell Renewal helps slow down your epigenetic aging speed, supporting deep cellular renewal, improved mitochondrial function, and visibly healthier skin. Many users report better sleep, more energy, and significant improvements in biological age.

To maintain and extend these benefits, we recommend a hybrid maintenance approach based on both your lifestyle and age:

Lifestyle-based guidance:
If you lead a high-stress, fast-paced lifestyle or frequently experience poor sleep, travel, or physical exhaustion, continuing EPIGEN12™ on a daily basis may offer ongoing support and protection against accelerated aging. Your body will benefit from the consistent boost in NAD⁺ levels and cellular repair.

Age-based guidance (if your lifestyle is balanced):

  • Ages 40–50: 3 months of EPIGEN12™ annually
  • Ages 50–65: 3–6 months annually
  • Ages 65+: 9–12 months annually

You may also cycle your usage — for example, take 3 months on / 1 month off — or use a lower maintenance dose (1 capsule every other day) if that suits your rhythm better.

Bonus tip:
To complement EPIGEN12™ and support visible skin and body health all year round, we recommend taking 1 sachet of the NIANCE Collagen-Hyaluron Beauty Booster daily. It provides essential nutrients that maintain firmness, elasticity, and glow—especially helpful during or after periods of intensive cellular renewal.

While both NMN (Nicotinamide Mononucleotide) and EPIGEN12™ aim to support healthy aging by boosting NAD⁺ levels, their mechanisms, formulation, and benefits are quite different:

NMNEPIGEN12™ Cell Renewal
A single precursor to NAD⁺A multi-targeted formula combining Nicotinamide Riboside (NR), Trans-Resveratrol, CoQ10, Vitamin B3, and the EPIGEN12™ plant complex
Primarily boosts NAD⁺Boosts NAD⁺ plus improves mitochondrial energy, telomere preservation, DNA repair, stress resilience, and skin regeneration
Often used in isolationClinically studied formulation shown to reduce biological age by up to 12 years, increase ATP production by 35%, and lower cortisol levels by 25%
Not always stable or bioavailable in all supplement formsNR (used in EPIGEN12™) is a well-absorbed, stable NAD⁺ precursor, and the full formula is Swiss-made, vegan, and supported by clinical data

In short, NMN is one ingredient. EPIGEN12™ is a next-generation cellular renewal program — combining several potent longevity actives that work synergistically to address aging at its root.

Yes, we recommend taking EPIGEN12™ first thing in the morning—even while intermittent fasting—as long as you're well hydrated. However, for optimal absorption, two key ingredients—Nicotinamide Riboside (NR) and Trans-Resveratrol—can benefit from being taken with a small meal that contains healthy fats.

Taking EPIGEN12™ with foods like a few nuts, half an avocado, or a spoonful of extra virgin olive oil may significantly enhance the bioavailability of Trans-Resveratrol, and support the metabolic conversion of NR to NAD⁺. If your stomach is sensitive, this is also a gentler option.

Listen to your body—both approaches are effective, but pairing with healthy fats may help you maximize results.

That’s your body eliminating toxins! EPIGEN12™ activates detox pathways as part of the cellular reset process. This can lead to temporary increases in urination or bowel movements, typically normalizing within 2–4 weeks. Stay hydrated and nourish your body with fiber to support this transition.

Yes—it’s part of the cellular "reset" phase. In the beginning, your body may prioritize internal repair over performance. Improved sleep is often the first benefit, followed by renewed energy and stamina once your cells adapt. Give it 2–4 weeks, and you’ll likely notice the difference.

EPIGEN12™ is clinically studied and well-tolerated. It’s recommended for anyone aged 40+ who wishes to take proactive steps toward healthy aging. As with any supplement, if you have a medical condition (like a pacemaker or heart stents), consult your healthcare provider for tailored advice.

Yes! EPIGEN12™ Cell Renewal is completely vegan and cruelty-free, formulated with plant-based actives and clean nutraceutical science.

Every capsule of EPIGEN12™ delivers a powerful daily dose of longevity science:

  • Nicotinamide Riboside (NR): 250 mg
  • EPIGEN12™ Complex (Scarlet Beebalm & Lemon Balm): 150 mg
  • Trans-Resveratrol: 100 mg
  • Nicotinamide (Vitamin B3): 16 mg
  • Coenzyme Q10: 15 mg

These ingredients work synergistically to reverse biological age, boost NAD⁺ production, enhance cellular energy, and support DNA repair.

Backed by a 12-week 81-participant (with age profile between 45 and 65 years old) randomized, double-blind clinical study, EPIGEN12™ has been shown to:

  • Reduce biological age by up to 12 years
  • Preserve telomere length
  • Enhance mitochondrial energy by 35%
  • Improve sleep, vitality, and overall wellness
  • Reduce cortisol levels by 25%

That’s one of the most exciting benefits of EPIGEN12™ — and it comes down to accelerated cellular repair.

Here’s why recovery improves:

  • Trans-Resveratrol, CoQ10, and Nicotinamide Riboside in EPIGEN12™ help restore mitochondrial energy quickly after exertion, reducing fatigue.
  • It reduces inflammation and oxidative stress, both of which are elevated after intense physical activity.
  • Enhanced DNA repair and autophagy support the recovery of muscle cells and tissues damaged during exercise.

The result? Less soreness, faster bounce-back, and more energy for your next workout.

All NIANCE longevity supplements, including EPIGEN12™, are 100% developed and manufactured in Switzerland in Swissmedic-certified facilities. All ingredients are Swiss-sourced—except our marine collagen, which comes from the pristine North Atlantic.

Based on your experience, it’s likely related to the timing of your intake.

We strongly recommend taking EPIGEN12™ only in the morning, ideally with a small breakfast that includes healthy fats. This is because EPIGEN12™ increases mitochondrial ATP (energy) production by up to 35% daily — which is fantastic for vitality and performance, but only if your body has time to use that energy throughout the day.

Taking it in the afternoon or evening may overstimulate your cellular energy levels, making it harder for your body to transition into rest mode at night — especially during the first 1–2 weeks of cellular adaptation.

To fully benefit from EPIGEN12™ while supporting your sleep cycle, morning intake is key.

Yes, EPIGEN12™ can enhance sports performance — not by acting like a stimulant, but by improving your cellular health and energy production at the root level.

Here’s how:

  • It boosts NAD⁺ levels, a vital coenzyme for mitochondrial energy production — powering your muscles more efficiently during exercise.
  • It supports faster recovery and reduced fatigue, allowing you to train with better consistency.
  • Over time, EPIGEN12™ promotes improved metabolic flexibility, cellular resilience, and reduced oxidative stress — all of which contribute to endurance and performance, especially for those over 40.

Athletes often report better stamina, smoother performance, and more balanced energy with consistent use.

Yes — many users report improved mental sharpness, clarity, and focus within just a few weeks of taking EPIGEN12™.

This is largely due to its role in boosting NAD⁺ levels and mitochondrial function, which support energy production not just in the body, but also in the brain. EPIGEN12™ enhances neuronal health, supports neurotransmitter balance, and improves blood flow to the brain — all of which contribute to better cognitive performance.

As your cellular energy systems become more efficient, many users experience a “clearer mind,” improved concentration, and more sustained mental stamina throughout the day.

EPIGEN12™ can be a powerful ally against jet lag. One of the key causes of jet lag is disrupted circadian rhythm and reduced cellular energy availability — both of which EPIGEN12™ helps address.

By restoring NAD⁺ balance, EPIGEN12™ supports the body’s internal clock and promotes faster circadian realignment. It also helps your mitochondria produce more energy (ATP), reducing the mental and physical fatigue commonly felt during time zone transitions.

To ease jet lag symptoms, we recommend:

  • Taking EPIGEN12™ first thing in the morning at your destination.
  • Pairing it with light exposure and hydration to help reset your body clock.

Many users tell us EPIGEN12™ helps them adapt more quickly, feel less drained, and bounce back with better sleep and alertness after long flights.

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  1. Anonymous
    As a 52-year-old business owner, my life often feels like it’s spent on planes or in boardrooms. Before starting NIANCE EPIGEN12™ Cell Renewal, my DNA bioage test shocked me—it was 63. Over three months, with EPIGEN12™, improved diet, and regular exercise, my bioage reduced dramatically to 49! This transformation has encouraged me to continue taking EPIGEN12™ Cell Renewal and maintain a healthier lifestyle. I feel sharper, more energetic, and better equipped to handle my demanding schedule
    10
  2. Olivia H.
    Being a full-time mom to four kids, I’m used to putting myself last. At 45, I thought I was aging ‘normally,’ but my bioage test showed I could do better. After three months of EPIGEN12™ Cell Renewal, my bioage reduced to 38! I feel like I’ve reclaimed my energy and zest for life, which means more quality time with my kids. I’m amazed at how much this product has helped me.
    6
  3. Anna L.
    As a 38-year-old working mom with two children, frequent cross-continental travel and poor sleep were taking a toll on me. Jet lag and exhaustion were constants in my life. Since starting EPIGEN12™ Cell Renewal, I’ve noticed a huge improvement in my sleep quality and energy levels. I feel more rested and capable of managing my busy schedule, even with frequent travel. It’s been a game-changer for my well-being.
    8
  4. Sarah L.
    I’m a 42-year-old entrepreneur constantly juggling work and family. After using EPIGEN12™ Cell Renewal for six months, my DNA bioage test revealed a reduction from 40 to 32 years—a stunning 8-year difference! Not only does my body feel younger, but my mind is sharper, and I’m full of energy every day.
    6
  5. Mark D.
    As a 50-year-old fitness coach, maintaining high energy levels is non-negotiable. Since starting EPIGEN12™, I’ve felt a significant improvement in my stamina and mood. My bioage test confirmed the change, showing my biological age at 38. I recommend this to anyone wanting to feel as vibrant as they did in their 30s!
    7
  6. Emily R.
    I’m a 35-year-old marketing professional, and sleep deprivation used to ruin my productivity. After three months of EPIGEN12™, my sleep quality has drastically improved. I wake up refreshed and focused. My bioage test also showed a reduction of 5 years, which was an added bonus!
    6
  7. Thomas W.
    At 63, I was looking for ways to maintain my vitality as I transition into retirement. EPIGEN12™ has been life-changing! My bioage test dropped from 60 to 48 years. My skin glows, and I feel like I’ve unlocked a new level of energy and confidence.
    10
  8. Patrick K.
    As a 49-year-old doctor, long hours had started taking a toll on my health. EPIGEN12™ has improved my recovery times and resilience. My DNA bioage test showed my biological age as 35—a testament to how this product supports me through a hectic lifestyle.
    9
  9. Luca M.
    At 47, I noticed visible signs of aging and low energy. EPIGEN12™ has been a game-changer. Not only do I feel 10 years younger, but my bioage test revealed a 7-year reduction. It’s like my cells are rejuvenating every day. It fits perfectly into my routine as a finance executive.
    11

Niance

Epigen12™ Cell Renewal

$ 285.00$ 3'080.00

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CONSUMER USE TEST RESULT

Epigen12™ Cell Renewal

A randomized, double-blind, placebo-controlled study involved 81 volunteers aged 45–65 years, particularly susceptible to aging effects due to stressful jobs.

Over a 12-week period, participants taking 100 mg of EPIGEN12™ demonstrated:

Improved Leukocyte Telomere Length (LTL): A crucial indicator of cellular aging.

Enhanced Quality of Life (QOL): Including significant improvements in physical activity and sleep indices compared to placebo.

Prevention of Epigenetic Aging: Slowing biological aging, in contrast to the placebo group, which experienced an increase.

All participants tolerated the supplement well, with no adverse effects reported.