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Niance

Epigen12™ Cell Renewal

Turning back the biological age clock by up to 12 years

EPIGEN12™ Cell Renewal is a revolutionary longevity supplement designed to turn back the biological clock by up to 12 years. With clinically proven results, this advanced formula tackles 9 hallmarks of aging, revitalizing your body at a cellular level for unparalleled rejuvenation and vitality.

Available on Preorder.
Next Shipment from 10th March 2025.
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$ 285.00 – $ 3'080.00

  • Available Worldwide
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What It Is

EPIGEN12™ Cell Renewal, a groundbreaking innovation in the fight against aging that redefines what’s possible in cellular rejuvenation. Clinically proven to turn back your biological clock by up to 12 years, this advanced formula addresses 9 out of 12 hallmarks of aging at the deepest level. Powered by the next-generation EPIGEN12™ extract, it delivers unparalleled benefits by reducing epigenetic aging, preserving telomere length, and revitalizing mitochondrial energy production. Enhanced with Trans-Resveratrol for superior bioavailability and a synergistic combination of Nicotinamide Riboside and Niacinamide, EPIGEN12™ Cell Renewal optimizes DNA repair, boosts NAD+ levels, and defends against oxidative stress, setting a new benchmark for anti-aging innovation. Experience a revolutionary approach to longevity, vitality, and quality of life with this transformative product—designed for those who demand the ultimate in cellular health and rejuvenation.

How It Works

EPIGEN12™ Cell Renewal leverages the power of cutting-edge epigenetics to restore youthful cellular function. By reducing epigenetic aging, preserving telomere length, and enhancing mitochondrial energy production, this supplement combats oxidative stress, supports DNA repair, and promotes overall cellular health. The formula is enriched with potent active ingredients to address multiple aging markers simultaneously, providing comprehensive anti-aging benefits.

Benefits

  • Reduces Biological Age: Clinically proven to turn back up to 12 biological years by addressing epigenetic aging.
  • Protects Telomere Length: Safeguards the integrity of telomeres to maintain cellular longevity.
  • Boosts Mitochondrial Energy: Enhances ATP production for improved energy levels and cellular function.
  • Boosts NAD+ Levels: Promotes NAD+ production, supporting energy metabolism and DNA repair.
  • Fights Oxidative Stress: Provides powerful antioxidant protection, reducing inflammation and genomic instability
  • Improves Quality of Life: Enhances physical activity, sleep quality, and overall wellness.

How To Use

  1. Take one capsule daily with a meal.
  2. Preferably consume it in the morning.
  3. Use consistently for optimal results.
  4. Continue usage for 6-9 months.
  5. Pair with a balanced diet and healthy lifestyle.

Science

EPIGEN12™

A next-generation, flavonoid-rich extract from scarlet beebalm and lemon balm, EPIGEN12™ has been clinically proven to:

  • Reduce epigenetic aging, equivalent to a reduction of up to 12 biological years.
  • Protect telomere length, preserving cellular longevity and counteracting telomere attrition.
  • Enhance mitochondrial function, boosting ATP production and defending against oxidative stress, addressing mitochondrial dysfunction.
  • Prevent cellular senescence, protecting cells from premature aging and supporting long-term vitality.
  • Promote vascular health by improving endothelial function, increasing nitric oxide release, and supporting healthy blood flow, mitigating dysregulated nutrient sensing and altered intercellular communication.
  • Provide powerful antioxidant protection, counteracting oxidative stress and inflammation, which can contribute to genomic instability, stem cell exhaustion, and chronic inflammation.

Consumer Trials

A randomized, double-blind, placebo-controlled study involved 81 volunteers aged 45–65 years, particularly susceptible to aging effects due to stressful jobs.

Over a 12-week period, participants taking 100 mg of EPIGEN12™ demonstrated:

Improved Leukocyte Telomere Length (LTL): A crucial indicator of cellular aging.

Enhanced Quality of Life (QOL): Including significant improvements in physical activity and sleep indices compared to placebo.

Prevention of Epigenetic Aging: Slowing biological aging, in contrast to the placebo group, which experienced an increase.

All participants tolerated the supplement well, with no adverse effects reported.

See All Results...

Clinical Trials

Conducted in laboratory settings using specialized assays and validated cellular models:

DNA Methylation Age (DNAmAge): Testing revealed a significant reduction in biological age up to 12 years.

Telomere Shortening Rate: EPIGEN12™ preserved telomere length, a key marker of cellular health, with statistically significant results (p < 0.01).

Mitochondrial ATP Production: Increased energy production in human heart cells, indicating enhanced cellular vitality (p < 0.001).

Vascular Function: Improved nitric oxide (NO) release in human endothelial cells, supporting healthy blood flow and nutrient sensing.

Nematode Healthspan Study: Demonstrated improved mobility and lifespan in medium-aged nematodes, correlating with enhanced healthspan.

EPIGEN12™ EFFICACY RESULTS

Telomere Shortening Rate

The control group showed a significantly higher telomere shortening rate compared to the group treated with 0.043 mg/mL of EPIGEN12™. This suggests that EPIGEN12™ may reduce the rate of telomere shortening, a marker of cellular aging.

Biological Age (DNA Methylation Age or DNAmAge)

The aged group treated with 0.03 mg/mL EPIGEN12™ displayed a reduction in biological age compared to the control group, indicating a potential age-reversing effect of EPIGEN12™.

Change in DNAmAge (Years)

Participants receiving EPIGEN12™ showed a lesser increase in DNAmAge compared to the placebo group, highlighting its potential in slowing biological aging.

Change in Leucocyte Telomere Length (LTL)

The placebo group experienced a reduction in LTL, while the EPIGEN12™ group showed an increase in telomere length.

ATP Production

EPIGEN12™ at 0.2 mg/mL significantly boosted ATP production compared to the control and Rotenone-treated groups.

Physical Activity and Sleep Index

A higher percentage of participants in the EPIGEN12™ group showed improvements in physical activity and sleep index compared to the placebo group.

Quality of Life (QOL)

The EPIGEN12™ group experienced a significant improvement in QOL compared to the placebo group, which showed a decline.

Nicotinamide Riboside (NR) + Niacinamide – A Synergistic Combination

The combination of NR and Niacinamide creates a powerful duo to support cellular metabolism and DNA repair.

Benefits:

  • NAD+ Precursor Enhancement: NR boosts NAD+ levels, essential for cellular energy production, while Niacinamide amplifies its efficacy.
  • Comprehensive DNA Repair: Together, they enhance the repair of damaged DNA, reducing genomic instability and protecting against aging triggers.
  • Dual Pathway Mitochondrial Support: NR promotes mitochondrial biogenesis, while Niacinamide strengthens mitochondrial integrity, ensuring sustained energy production.
  • Skin Health and Barrier Function: Niacinamide adds benefits for skin hydration, elasticity, and overall resilience, complementing NR’s intracellular anti-aging effects.

Trans-Resveratrol – A Superior Longevity Activator - The Triple-Biotics Power

A next-generation form of resveratrol, Trans-Resveratrol is more bioavailable and potent compared to conventional resveratrol.

Unique Benefits:

✓ Enhanced Bioavailability: Trans-Resveratrol is more efficiently absorbed by the body, delivering faster and more effective results.
✓ Activates Sirtuins for Longevity: Boosts mitochondrial function, supporting cellular energy and delaying aging processes.
✓ Superior Antioxidant Properties: Provides robust protection against oxidative stress, reducing DNA damage and inflammation.
✓ Improves Skin Health: Supports elasticity and hydration while reducing visible signs of aging.

Key Ingredients​

Our Promises

Additional information

Unit

30 Capsules

Packing

Bottle

Epigen12™, Trans-Resveratrol, Nicotinamide Riboside (NR), Niacinamide (Vitamin B3), Coenzym Q10

Please keep the product in the dry and cool environment. Keep away from children.

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  1. Anonymous
    As a 52-year-old business owner, my life often feels like it’s spent on planes or in boardrooms. Before starting NIANCE EPIGEN12™ Cell Renewal, my DNA bioage test shocked me—it was 63. Over three months, with EPIGEN12™, improved diet, and regular exercise, my bioage reduced dramatically to 49! This transformation has encouraged me to continue taking EPIGEN12™ Cell Renewal and maintain a healthier lifestyle. I feel sharper, more energetic, and better equipped to handle my demanding schedule
    6
  2. Olivia H.
    Being a full-time mom to four kids, I’m used to putting myself last. At 45, I thought I was aging ‘normally,’ but my bioage test showed I could do better. After three months of EPIGEN12™ Cell Renewal, my bioage reduced to 38! I feel like I’ve reclaimed my energy and zest for life, which means more quality time with my kids. I’m amazed at how much this product has helped me.
    5
  3. Anna L.
    As a 38-year-old working mom with two children, frequent cross-continental travel and poor sleep were taking a toll on me. Jet lag and exhaustion were constants in my life. Since starting EPIGEN12™ Cell Renewal, I’ve noticed a huge improvement in my sleep quality and energy levels. I feel more rested and capable of managing my busy schedule, even with frequent travel. It’s been a game-changer for my well-being.
    7
  4. Sarah L.
    I’m a 42-year-old entrepreneur constantly juggling work and family. After using EPIGEN12™ Cell Renewal for six months, my DNA bioage test revealed a reduction from 40 to 32 years—a stunning 8-year difference! Not only does my body feel younger, but my mind is sharper, and I’m full of energy every day.
    5
  5. Mark D.
    As a 50-year-old fitness coach, maintaining high energy levels is non-negotiable. Since starting EPIGEN12™, I’ve felt a significant improvement in my stamina and mood. My bioage test confirmed the change, showing my biological age at 38. I recommend this to anyone wanting to feel as vibrant as they did in their 30s!
    6
  6. Emily R.
    I’m a 35-year-old marketing professional, and sleep deprivation used to ruin my productivity. After three months of EPIGEN12™, my sleep quality has drastically improved. I wake up refreshed and focused. My bioage test also showed a reduction of 5 years, which was an added bonus!
    5
  7. Thomas W.
    At 63, I was looking for ways to maintain my vitality as I transition into retirement. EPIGEN12™ has been life-changing! My bioage test dropped from 60 to 48 years. My skin glows, and I feel like I’ve unlocked a new level of energy and confidence.
    8
  8. Patrick K.
    As a 49-year-old doctor, long hours had started taking a toll on my health. EPIGEN12™ has improved my recovery times and resilience. My DNA bioage test showed my biological age as 35—a testament to how this product supports me through a hectic lifestyle.
    6
  9. Luca M.
    At 47, I noticed visible signs of aging and low energy. EPIGEN12™ has been a game-changer. Not only do I feel 10 years younger, but my bioage test revealed a 7-year reduction. It’s like my cells are rejuvenating every day. It fits perfectly into my routine as a finance executive.
    8

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Epigen12™ Cell Renewal

$ 285.00 – $ 3'080.00

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CONSUMER USE TEST RESULT

Epigen12™ Cell Renewal

A randomized, double-blind, placebo-controlled study involved 81 volunteers aged 45–65 years, particularly susceptible to aging effects due to stressful jobs.

Over a 12-week period, participants taking 100 mg of EPIGEN12™ demonstrated:

Improved Leukocyte Telomere Length (LTL): A crucial indicator of cellular aging.

Enhanced Quality of Life (QOL): Including significant improvements in physical activity and sleep indices compared to placebo.

Prevention of Epigenetic Aging: Slowing biological aging, in contrast to the placebo group, which experienced an increase.

All participants tolerated the supplement well, with no adverse effects reported.