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Niance

Early Aging Defense Protocol

“Botox-like” Aesthetic Effect Triangle

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$ 1'800.00 every 3 months

What it is

Preserve · Protect · Strengthen
Typically suited for 20–35 or early signs of aging

Begin here if you are noticing:

early fine lines or dehydration
uneven tone or increased sensitivity
greater impact from UV, pollution, or stress

This protocol focuses on prevention and resilience, addressing early inflammaging and oxidative stress to preserve long-term skin youthfulness.

Each Delivery Includes:

1 x Cleansing Gel PURIFY (150ml)

1 x Facial Tonic REFRESH (100ml)

1 x Hydrating Mask INTENSIFY (50ml)

1 x Day Care PERFECT (50ml)

1 x Night Care REGENERATE (50ml)

1 x Eye Care SHINE (15ml)

1 x Cleansing Peeling ENERGIZE (60ml)

1 x Sun Protection Fluid COMPLETE SPF50 (50ml)

How it works

NIANCE Premium Glacier Facial Oil works through a multi-pathway biological approach, complementing the Serum and Cream within the Glacial Platinum system.

It focuses on neuro-cosmetic relaxation, dermal biomechanical tightening, and retinoid-pathway renewal, delivered through an elegant oil matrix that enhances efficacy and tolerance.

1. Neuro-cosmetic relaxation & visible smoothing

Key actives such as Stoechiol® (Butterfly Lavender) help relax chronic facial tension, soften expression lines, and improve skin micro-relief—without freezing facial movement.

This creates an immediately smoother, calmer, and more refined appearance.

2. Dermal biomechanical tightening

Acmella oleracea extract supports dermal biomechanical activity by influencing fibroblast contractility and reinforcing structural integrity within the skin. This activity helps improve firmness and contributes to a visibly tighter and more lifted appearance, particularly in areas prone to expression lines and signs of fatigue.

This tightening effect complements neuromuscular signal modulation delivered by Syn-Ake in the Serum and Cream, reinforcing the overall Botox-like outcome at tissue level.

3. Retinoid-pathway renewal without irritation

Bakuchiol, a clinically proven retinol alternative, together with NovoRetin™ O (Chios mastic gum) and Samphira Oil Bioactive, supports skin renewal, pore refinement, and texture improvement—without irritation or photosensitivity.

This allows continuous day-and-night use while maintaining excellent skin tolerance.

4. Lipid nourishment & antioxidant protection

A refined blend of squalane, sunflower seed oil, sesame oil, and vitamin E + Coenzyme Q10 strengthens the skin barrier, improves suppleness, and protects against oxidative stress, ensuring long-term skin resilience.

Benefits

Immediate smoothing and relaxation of expression lines
Visible improvement in firmness and skin density
Refined pores and improved skin texture
Retinol-like renewal without irritation
Strengthened skin barrier and enhanced radiance
Elegant, lightweight oil texture with fast absorption

Botox-Like Aesthetic Effect Triangle

NIANCE Premium Glacier Facial Oil delivers a visible smoothing and firming effect through a three-directional biological strategy. The formula targets key mechanisms involved in the appearance of expression lines and skin firmness.

• Neuro Relaxation — Stoechiol®
Helps reduce facial micro-tension associated with expression lines for a smoother appearance.

• Dermal Tightening — Acmella oleracea
Supports dermal biomechanical activity to enhance skin firmness and improve structural integrity.

• Long-Term Renewal — Bakuchiol + Mastic (NovoRetin™ O)
Promotes gentle retinoid-pathway activation to support skin renewal and improve texture over time.

By addressing these complementary pathways simultaneously, the formula helps smooth expression lines, enhance firmness and support a visibly refined, rejuvenated skin appearance.

Highlights

A Multi-Pathway Biological Strategy

NIANCE Premium Glacier Facial Oil addresses multiple biological drivers of skin aging through an integrated, multi-pathway approach:

Neuro-cosmetic modulation to help relax facial micro-tension
Dermal biomechanical support to enhance firmness and structural integrity
Retinoid-pathway activation to promote renewal and texture refinement

By simultaneously supporting skin communication, structural resilience, and cellular renewal, the formula delivers immediate aesthetic refinement while contributing to long-term skin longevity — fully aligned with NIANCE’s Hallmarks of Aging framework.

FERNESSE™ Biotechnology - The Triple-Biotics Power

The ground-breaking FERNESSE™ biotechnology of NIANCE is revolutionizing the concept of holistic anti-aging inside out, by releasing the full Triple-Biotics power (pre-, pro- and post-biotics) of active ingredients and drastically increase the bio-availability of nutrients. FERNESSE™ ensures our skincare and supplements deliver optimal results quickly and efficiently.

EFFICACY STUDY RESULTS

Neuro-Cosmetic Relaxation

1. Beta-Endorphin Release

Model: Human keratinocytes
Exposure: 6 hours
+36% beta-endorphin release at 0.001
+41% at 0.01%
Beta-endorphins are endogenous relaxing neuro-messengers that contribute to visible softening of tension lines.

Neuro-Cosmetic Relaxation

2. Nerve–Muscle Model – Contraction Inhibition

Observation period: 24 hours
Significant reduction in contraction frequency
Muscle contraction suppressed
Full recovery of contraction after removal (reversible effect)
No cytotoxicity observed
These findings confirm a reversible, non-toxic neuro-cosmetic relaxation mechanism.

Epidermal Redensification & Retinoid Pathway Activation

3. CRABP-II Expression

35% increase in CRABP-II expression
+24% increase in epidermal thickness
CRABP-II is a key marker associated with epidermal renewal and retinoid activity.

Collagen & Extracellular Matrix Support

4. Collagen Stimulation

+94% increase in Collagen I synthesis

Collagen & Extracellular Matrix Support

5. Reduced Collagen Breakdown

−71% reduction in MMP1 expression (collagen degradation marker)

Clinical Trials

28-Day Clinical Study (Women aged 46–59 | Twice daily)

Reduction in total wrinkle count
−13% reduction in wrinkle surface area
Up to −17.4% reduction in wrinkle depth within 24 hours
Effects measurable 7 days after treatment cessation

Immediate Hydration (Single application)

+11.6% increase in hydration at 2 hours
Hydration maintained up to 7 hours

28-Day Clinical Study (Women aged 42–70)

+20.4% improvement in skin elasticity
+13.8% increase in dermal density

Immediate Smoothing (Single application)

−14% reduction in wrinkle depth
−13.7% reduction in wrinkle length
−6.4% reduction in skin roughness

Pore Refinement (28 Days)

Significantly refined pores:

by more than 8% after 14 days
by almost 15% after 28 days

−30.3% reduction in pore count
−41.7% reduction in pore volume

Significantly reduced both types of retentional lesions:

Blackheads were reduced by almost 40%
Microcysts were reduced by almost 30%

Sebum Regulation (14 Days)

−11% reduction in sebum output
Increased skin hydration
No drying effect observed

Skin Brightness Study (28 Days | Panel: 72 women)

+1.4% increase in skin lightness (L*)
+1.8% increase in brightness
+2.4% increase in luminosity
88% of participants observed visible improvement

Consumer Trials

Key Ingredients

How to use

Use morning and/or evening as part of your Glacial Platinum routine.

Cleanse thoroughly to prepare the skin.
Apply Premium Glacier Facial Serum and allow it to absorb.
Warm 2–4 drops of Premium Glacier Facial Oil between your palms.
Gently press onto face, neck, and décolleté using upward motions.
Follow with Premium Glacier Facial Cream to seal and prolong the effect.

Additional information

Refill	Every 3 months

Ingredients

Caprylic/Capric Triglyceride, Sesamum Indicum (Sesame) Seed Oil, Glycine Soja (Soybean) Oil, Pentylene Glycol, Helianthus Annuus (Sunflower) Seed Oil, Polyglyceryl-3 Polyricinoleate, Acmella Oleracea Extract, Pistacia Lentiscus (Mastic) Gum, Amaranthus Caudatus Seed Extract, Rosmarinus Officinalis (Rosemary) Leaf Extract, Squalane, Tocopheryl Acetate, Ubiquinone, Parfum (Fragrance), Crithmum Maritimum Extract, Tocopherol, Lavandula Stoechas Extract, Bakuchiol, Ascorbyl Palmitate

Storage Instruction

Please keep the product in the dry and cool environment. Please finish using the product within 6 months after opening.

1. What makes NIANCE Premium Glacier Facial Oil different from other facial oils?

2. What does “Botox-like Effect” mean at NIANCE?

3. Is the Botox-like effect only delivered by the facial oil?