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Epigen12™ Cell Renewal is a next-generation epigenetic longevity supplement designed to reverse biological (epigenetic) age by targeting DNA methylation, mitochondrial signaling, and cellular senescence — the root drivers of aging.

È pensato per chi vuole gestire attivamente la velocità di invecchiamento biologico del proprio corpo, in particolare per i professionisti, i dirigenti e le persone ad alto rendimento che cercano vitalità a lungo termine piuttosto che stimoli a breve termine.

Chronological age cannot be changed, but biological age can accelerate or slow down. Epigen12™ addresses accelerated biological aging caused by stress, lifestyle pressure, metabolic imbalance, and cellular dysfunction.

Epigen12™ modulates epigenetic regulation (DNA methylation), supports NAD⁺-dependent mitochondrial communication, and reduces senescence-associated cellular dysfunction — helping cells behave more youthfully.

Unlike NAD⁺ boosters or performance supplements, Epigen12™ is clinically validated to impact epigenetic aging itself, not just energy or symptoms. It targets how aging is programmed at the cellular level.

Epigen12™ contains a proprietary epigenetic complex combined with trans-resveratrol, nicotinamide riboside (NR), niacinamide (vitamin B3), and coenzyme Q10 — designed to act synergistically on epigenetic and mitochondrial pathways.

Epigen12™ has been evaluated in an 81-participant, double-blind, randomized, placebo-controlled human study, where it was shown to reverse biological (epigenetic) age by up to 12 years, measured using DNA methylation biomarkers.

L'età biologica riflette la velocità di invecchiamento del corpo a livello cellulare e molecolare. Invertire la tendenza significa migliorare i biomarcatori epigenetici in modo che le cellule funzionino come quelle di uno stato biologico più giovane.

L'invecchiamento biologico si misura a livello molecolare. I miglioramenti nella vitalità, nella qualità del sonno e nella resilienza possono essere percepiti nel giro di poche settimane, mentre i cambiamenti epigenetici dell'età sono tipicamente valutati nel corso di mesi attraverso l'analisi dei biomarcatori.

Epigen12™ represents the epigenetic reprogramming phase of the system. It is most effective when used after the body has been prepared through microbiome optimization and Holistic Body Reset.

Epigenetic reprogramming requires a metabolically clear and resilient system. Holistic Body Reset restores detoxification capacity, reduces toxic load, and re-ignites metabolism, creating the optimal biological environment for Epigen12™ to work effectively.

Yes. Epigen12™ is designed to work synergistically with GENR8® Biotic Supplements, Holistic Body Reset, and Collagen-Hyaluron Beauty Booster as part of an integrated longevity system.

Epigen12™ is developed and manufactured in Switzerland under strict quality and safety standards. Its formulation is designed for long-term use to support sustainable biological aging management.

Yes. Epigenetic aging affects both men and women, and Epigen12™ is suitable for both genders.

Yes. Biological aging acceleration often becomes more pronounced after 40, making Epigen12™ particularly relevant for individuals in midlife and beyond.

No. Epigen12™ complements a healthy lifestyle by supporting biological mechanisms that lifestyle alone cannot fully address, especially under modern stress conditions.

L'invecchiamento biologico è continuo. L'interruzione significa che l'organismo non è più supportato a livello epigenetico e i processi di invecchiamento continuano in base allo stile di vita e ai fattori ambientali.

Traditional anti-aging products focus on appearance or symptoms. Epigen12™ focuses on how cells age, addressing the biological root rather than surface effects.

La Svizzera offre standard leader a livello mondiale nel campo della biotecnologia, della regolamentazione dei prodotti nutraceutici e della ricerca clinica. I prodotti NIANCE sono sviluppati e prodotti in Svizzera per garantire precisione, sicurezza e integrità scientifica.

Epigen12™ Cell Renewal is a clinically validated epigenetic longevity supplement designed to reverse biological age and reset how the body ages from within.

During the first 6–9 months of consistent use, EPIGEN12™ Cell Renewal helps slow down your epigenetic aging speed, supporting deep cellular renewal, improved mitochondrial function, and visibly healthier skin. Many users report better sleep, more energy, and significant improvements in biological age.

Per mantenere e prolungare questi benefici, consigliamo un approccio di manutenzione ibrido, basato sullo stile di vita e sull'età:

Guida basata sullo stile di vita:
If you lead a high-stress, fast-paced lifestyle or frequently experience poor sleep, travel, or physical exhaustion, continuing EPIGEN12™ on a daily basis may offer ongoing support and protection against accelerated aging. Your body will benefit from the consistent boost in NAD⁺ levels and cellular repair.

Guida in base all'età (se lo stile di vita è equilibrato):

• Ages 40–50: 3 months of EPIGEN12™ annually
• Ages 50–65: 3–6 months annually
• Ages 65+: 9–12 months annually

You may also cycle your usage — for example, take 3 months on / 1 month off — or use a lower maintenance dose (1 capsule every other day) if that suits your rhythm better.

Suggerimento bonus:
To complement EPIGEN12™ and support visible skin and body health all year round, we recommend taking 1 bustina di NIANCE Collagen-Hyaluron Beauty Booster al giorno. It provides essential nutrients that maintain firmness, elasticity, and glow—especially helpful during or after periods of intensive cellular renewal.

While both NMN (Nicotinamide Mononucleotide) and EPIGEN12™ aim to support healthy aging by boosting NAD⁺ levels, their mechanisms, formulation, and benefits are quite different:

In short, NMN is one ingredient. EPIGEN12™ is a next-generation cellular renewal program — combining several potent longevity actives that work synergistically to address aging at its root.

Yes, we recommend taking EPIGEN12™ first thing in the morning—even while intermittent fasting—as long as you're well hydrated. However, for optimal absorption, two key ingredients—Nicotinamide Riboside (NR) and Trans-Resveratrol—can benefit from being taken with a small meal that contains healthy fats.

Taking EPIGEN12™ with foods like a few nuts, half an avocado, or a spoonful of extra virgin olive oil may significantly enhance the bioavailability of Trans-Resveratrol, and support the metabolic conversion of NR to NAD⁺. If your stomach is sensitive, this is also a gentler option.

Listen to your body—both approaches are effective, but pairing with healthy fats may help you maximize results.

That’s your body eliminating toxins! EPIGEN12™ activates detox pathways as part of the cellular reset process. This can lead to temporary increases in urination or bowel movements, typically normalizing within 2–4 weeks. Stay hydrated and nourish your body with fiber to support this transition.

Yes—it’s part of the fase di "reset" cellulare. In the beginning, your body may prioritize internal repair over performance. Improved sleep is often the first benefit, followed by renewed energy and stamina once your cells adapt. Give it 2–4 weeks, and you’ll likely notice the difference.

EPIGEN12™ is clinically studied and well-tolerated. It’s recommended for anyone aged 40+ who wishes to take proactive steps toward healthy aging. As with any supplement, if you have a medical condition (like a pacemaker or heart stents), consult your healthcare provider for tailored advice.

Yes! EPIGEN12™ Cell Renewal is completely vegan e cruelty-freeformulata con principi attivi di origine vegetale e una scienza nutraceutica pulita.

Every capsule of EPIGEN12™ delivers a powerful daily dose of longevity science:

• Nicotinamide Riboside (NR): 250 mg
• EPIGEN12™ Complex : 150 mg
• Trans-Resveratrolo: 100 mg
• Nicotinamide (vitamina B3): 16 mg
• Coenzima Q10: 15 mg

Questi ingredienti lavorano in sinergia per invertire l'età biologica, spinta NAD⁺ production, migliorare energia cellularee supporto Riparazione del DNA.

Backed by a 12-week 81-participant (with age profile between 45 and 65 years old) randomized, double-blind clinical study, EPIGEN12™ has been shown to:

• Ridurre l'età biologica fino a 12 anni
• Conservare lunghezza dei telomeri
• Migliorare energia mitocondriale da 35%
• Migliorare sonno, vitalità e benessere generale
• Ridurre livelli di cortisolo da 25%

That’s one of the most exciting benefits of EPIGEN12™ — and it comes down to accelerated cellular repair.

Here’s why recovery improves:

• Trans-Resveratrol, CoQ10, and Nicotinamide Riboside in EPIGEN12™ help restore mitochondrial energy quickly after exertion, reducing fatigue.
• Riduce l'infiammazione e lo stress ossidativo, entrambi elevati dopo un'intensa attività fisica.
• Il potenziamento della riparazione del DNA e dell'autofagia favorisce il recupero delle cellule muscolari e dei tessuti danneggiati durante l'esercizio fisico.

Il risultato? Meno indolenzimento, recupero più rapido e più energia per l'allenamento successivo.

All NIANCE longevity supplements, including EPIGEN12™, are 100% sviluppato e prodotto in Svizzera in Certificato Swissmedic facilities. All ingredients are Swiss-sourced—except our marine collagen, which comes from the pristine North Atlantic.

Based on your experience, it’s likely related to the timing of your intake.

We strongly recommend taking EPIGEN12™ only in the morning, ideally with a small breakfast that includes healthy fats. This is because EPIGEN12™ increases mitochondrial ATP (energy) production by up to 35% daily — which is fantastic for vitality and performance, but only if your body has time to use that energy throughout the day.

Taking it in the afternoon or evening may overstimulate your cellular energy levels, making it harder for your body to transition into rest mode at night — especially during the first 1–2 weeks of cellular adaptation.

To fully benefit from EPIGEN12™ while supporting your sleep cycle, morning intake is key.

Yes, EPIGEN12™ can enhance sports performance — not by acting like a stimulant, but by improving your cellular health and energy production at the root level.

Here’s how:

• It boosts NAD⁺ levels, a vital coenzyme for mitochondrial energy production — powering your muscles more efficiently during exercise.
• Favorisce un recupero più rapido e una riduzione dell'affaticamento, consentendo di allenarsi con maggiore costanza.
• Over time, EPIGEN12™ promotes improved metabolic flexibility, cellular resilience, and reduced oxidative stress — all of which contribute to endurance and performance, especially for those over 40.

Gli atleti spesso riferiscono di una migliore resistenza, di prestazioni più fluide e di un'energia più equilibrata con un uso costante.

Yes — many users report improved mental sharpness, clarity, and focus within just a few weeks of taking EPIGEN12™.

This is largely due to its role in boosting NAD⁺ levels and mitochondrial function, which support energy production not just in the body, but also in the brain. EPIGEN12™ enhances neuronal health, supports neurotransmitter balance, and improves blood flow to the brain — all of which contribute to better cognitive performance.

As your cellular energy systems become more efficient, many users experience a “clearer mind,” improved concentration, and more sustained mental stamina throughout the day.

EPIGEN12™ can be a powerful ally against jet lag. One of the key causes of jet lag is disrupted circadian rhythm and reduced cellular energy availability — both of which EPIGEN12™ helps address.

By restoring NAD⁺ balance, EPIGEN12™ supports the body’s internal clock and promotes faster circadian realignment. It also helps your mitochondria produce more energy (ATP), reducing the mental and physical fatigue commonly felt during time zone transitions.

Per alleviare i sintomi del jet lag, si consiglia di

• Taking EPIGEN12™ first thing in the morning at your destination.
• Abbinarlo all'esposizione alla luce e all'idratazione aiuta a resettare l'orologio del corpo.

Many users tell us EPIGEN12™ helps them adapt more quickly, feel less drained, and bounce back with better sleep and alertness after long flights.